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Importantly, GLP-1R is expressed in adipose tissue, in both the stromal vascular and the adipocyte fraction and its expression level has been found to correlate with the degree of insulin resistance 46

Accordingly, drug-mediated regulation of Wnt/-catenin signalling activity to induce liver regeneration would benefit this group of patients based on the key role of Wnt/-catenin signalling in the pathobiology of non-tumour diseases such as steatohepatitis, 78,310 cholestasis, 311 and liver fibrosis

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Autonomic disturbances can also occur between episodes, such as reflex sympathetic dystrophy (a chronic pain condition), syncope/POTS (fainting) and disorders of gastrointestinal motility