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doi: 10.1016/j.lfs.2017.12.015 209 GnoniALongoSGnoniGVGiudettiAM

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Its activity profile is best understood as systems-level: published in vitro and in vivo work has documented effects on fibroblast proliferation, collagen and growth-factor receptor expression, endothelial migration, nitric oxide system signalling, and dopamine and serotonin pathway markers

Jang S, Chapa-Dubocq XR, Tyurina YY, St Croix CM, Kapralov AA, Tyurin VA, et al

Its approval was supported by data from the Phase III CAHtalyst study, which demonstrated that Crenessity significantly lowered androstenedione concentrations in both adult and pediatric patients, allowing them to taper glucocorticoid doses without affecting treatment efficacy