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120,121 In atherosclerosis, a metabolic disease driven by chronic inflammation and faulty lipid metabolism, E3 ligases such as FBXW2 and FBXO3 have been identified as key modulators of vascular inflammation

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A combination of prolonged oxidative damage and hepatocellular proliferation is postulated to be responsible for liver tumor development, with tumor development primarily a result of enhanced growth of preneoplastic foci