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Since lipid-derived Acetyl-CoA is one of the major sources of carbons for histone acetylation, the authors also showed that exogenous lactate induces increased levels of specific histones acetylation (in particular H3K9 and H3K27) that correlate with an open state of the chromatin, suggesting an active gene transcription

The precise pathways through which gut-derived immune signals influence the CNS, the relative contributions of different immune populations, and the extent to which microbiota-targeted interventions can modulate brain function are still unclear

Dermatologic Surgery, 51(2), 198-207

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