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Key substrates are phosphorylated by PKA, which are involved in insulin synthesis and secretion [31]

Novo Nordisk recommends those sites likely because you tend to have more layers of fat under the skin in those areas

Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

ectopic expression of Lmx1a and Lmx1b can induce VTA DA neuron generation in ectopic locations, whereas loss of Lmx1b markedly reduces the VTA DA neuron population (Nakatani et al., 2010)