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However, most previous studies have not considered leptins powerful cardiac effects that are mediated via activation of central nervous system (CNS) leptin receptors (LepRs) which, in turn, elicit major improvements in cardiac metabolism

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Hao J (2021) Microglial PGC-1alpha protects against ischemic brain injury by suppressing neuroinflammation

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Indirect mechanisms including substantially reduced food intake, gastrointestinal symptoms, and rapid weight loss may potentially affect iron status during treatment