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Clinical trials (STEP programme) have demonstrated significant weight loss, with participants losing an average of 12-15% of their initial body weight over 68 weeks when combined with lifestyle interventions

A provider can help determine which option may be appropriate for your goals

People taking MAO inhibitors cannot take bupropion at all, which means the combination with tirzepatide is irrelevant for this group

Weight gain and weight loss is a complex interaction of multiple hormones, says Mir Ali, MD, the medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California

Individual experiences can vary widely with these medicines