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This effect tends to be most pronounced early in treatment and may diminish over time with continued use

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However, members in high-deductible health plans or those with coinsurance may pay less out-of-pocket because their cost sharing is tied to the list price

In another real-world analysis of 945 patients, those on tirzepatide lost an average of 6.6 kg versus 3.1 kg on semaglutide over six months