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Glandular lumen may contain granular eosinophilic material and sometime free blood cells

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found, in CD4+ and CD8+ cells from patients with Graves disease, hypermethylated CpG sites in genes involved in T cell signalling.36 Other authors have found both hypermethylation30,37 and hypomethylation30,37,38 in genes involved in the immune and inflammatory response in peripheral blood leukocytes from patients with Graves disease

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