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Incretin mimetics (GLP-1 receptor agonists such as semaglutide) are mostly injectable agents that stimulate insulin only when glucose is raised, suppress glucagon, slow gastric emptying, and promote satiety

Magnolia bark has been traditionally used in medical practices throughout much of Southeast Asia and has become widely studied by scientists for its pleiotropic effects

Activation of hepatic GPER1 leads to cAMP release and AMPK-mediated signaling (11), and activation of membrane-bound ER triggers the protein kinase A-liver kinase B-AMPK signaling pathway, increasing phosphorylation of ACC and SREBP1 (20)

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Body composition: DEXA scan at baseline, 12 weeks, and 24 weeks minimum