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This was made clear during the COVID-19 pandemic, with pharmacists overwhelmed not only by demand for medicines but by patients seeking guidance

GLP-1R signals through G-protein-dependent, and G-protein-independent pathways by engaging the scaffold protein -arrestin

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This reparative effect is mediated, at least in part, through the upregulation and reorganization of key regulatory proteins, most notably protein kinase C (PKC) and the tight junction scaffolding protein zonula occludens-2 (ZO-2), thereby facilitating the reassembly and functional recovery of the tight junction complex (161)