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Certain health conditions such as intestinal or stomach problems, poor nutrition, cancer, HIV, pregnancy, old age, veganism and alcoholism can cause vitamin B12 deficiency

Individuals with severe kidney failure, decompensated liver disease, congestive heart failure with fluid overload, non-ketonic hyper-glycemia, or known hypersensitivity to formulation components should not receive glycine.Patients on clozapine should likewise avoid glycine unless supervised closely, as it may blunt clozapines efficacy

References Vitamin B12 Product Label Cyanocobalamin injection [package insert]

If you know your levels are low, B12 supplements are a great start, but you're going to be playing catch-up, so dont expect things to be back to normal immediately

Preeclampsia, placental rupture, spontaneous abortion, and miscarriage are all linked to elevated plasma homocysteine levels