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Its also thought that isotretinoin can contribute to carnitine deficiency, which can explain why some of our patients experience muscle soreness while on treatment. In a study that investigated the efficacy of reducing isotretinoin-induced myalgias with L-carnitine, 40 of 230 patients who were taking isotretinoin were found to have myalgias

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Some supplements contain more or less melatonin than expected, along with added ingredients such as herbs or sugars