In the case of some deficiencies, notably those of glutathione synthetase (GS), TPI, and phosphoglycerate kinase (PGK), the defect is expressed throughout the body, and neurologic and other defects may be a prominent part of the clinical syndrome
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This state can also trigger Metabolic Conservation, where mitochondriathe cellular energy factoriesdownshift energy output in an effort to conserve fuel in response to perceived stress
However, the dual action may: Intensify this effect Make it more likely to occur Make it harder for the body to compensate 4
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