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84 OhashiR.TamaiI.InanoA.KatsuraM.SaiY.NezuJ.et al (2002)

The complexity arises from the individual mechanisms of action of each substance

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Important safety considerations include the risk of acute pancreatitis (seek urgent medical attention for severe, persistent abdominal pain), gallbladder disease, and potential worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy who experience rapid improvement in blood glucose control