Lyophilisation helps preserve peptide stability during storage and transport, while reconstitution prepares the compound for controlled experimental handling
Taranta A, Elmonem MA, Bellomo F, De Leo E, Boenzi S, Janssen MJ, Jamalpoor A, Cairoli S, Pastore A, De Stefanis C, Colucci M, Rega LR, Giovannoni I, Francalanci P, van den Heuvel LP, Dionisi-Vici C, Goffredo BM, Masereeuw R, Levtchenko E, Emma F (2021) Benefits and toxicity of disulfiram in preclinical models of nephropathic cystinosis
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They provided way more data, visibility, and ease of use than we were getting before, even more than we thought we needed
The primary mechanisms of action include enhanced insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is released only when blood glucose levels are elevated