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Moreover, despite the encouraging preclinical data, rigorous phase III trials are necessary to confirm the safety, tolerability, and specificity of GLP-1RAs in pain management

10.1097/GRF.0b013e3181db7d71 32

The 48-week extension trial (TIPO-4) demonstrated sustained efficacy, with participants maintaining a total mean weight loss of 13-14kg over the extended treatment period, confirming long-term effectiveness without significant tolerance development

Remote and Rural Patient Populations With longer transit times and exposure to unpredictable ambient conditions, rural deliveries present greater challenges