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Effect of minocycline on depressive symptoms in patients with treatment-resistant depression: a randomized clinical trial

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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

The 0.25 mg dose is a starter dose, not a treatment dose, so it is meant to get you going rather than to manage blood sugar on its own