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Retatrutide is currently an investigational drug that is not yet FDA-approved for weight loss

Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

This occurs through multiple signaling cascades including the cAMP responsive element-binding protein (CREB) pathway

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