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A handful of recent observational studies have linked GLP-1s to lower cancer risks or improved outcomes in cancer survivors

In SUSTAIN-6 trial similar effects in MACE risk reduction, glycemic control and hypoglycemia rates were observed in patients receiving 0.5 mg semaglutide once weekly and in those receiving 1 mg once weekly ( Mechanisms related to cardiovascular effects of GLP-1 receptor agonists The cardiovascular effects of GLP-1 receptor agonists in CVOTs can be attributed to several mechanisms

This finding suggests the need to reevaluate their use in patients who experience RLS or are at high risk for developing it. The U.S