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Patients still need appropriate management of blood pressure, cholesterol, blood sugar, sleep apnea, smoking status, nutrition, exercise, and cardiology follow-up when needed

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Although the currently approved treatments with GLP-1R agonists demonstrate remarkable antidiabetic effects, further improvements in this class are expected such as long-term glucose control 29

The combination of pathways distinguishes tirzepatide's pharmacological profile and explains why clinical responses often diverge between the two medications

Semaglutide slows stomach emptying, potentially reducing absorption rates