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Senior Investigator Carolyn Beebe Smith in the National Institute of Mental Health (NIMH) is exploring this essential question by imaging the brain during wakefulness and sleep and by correlating brain-protein metabolism with learning and memory

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Specific pathways affected include TGF-beta superfamily signaling, Wnt signaling, antioxidant defense (including superoxide dismutase, glutathione S-transferases, and thioredoxin reductase), and DNA repair mechanisms