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doi: 10.1371/journal.pone.0159085 75 YaoJ.HuotB.FouneC.DoddapaneniH.EnyediA

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Research has examined Semaglutides effects on dopaminergic reward circuit biology , characterising attenuation of substance reward responses and addiction-associated behaviours through GLP-1R-mediated dopamine system modulation in the nucleus accumbens and ventral tegmental area , and neuroprotective effects in neurodegenerative models through GLP-1R-mediated neuroinflammation attenuation, microglial activation modulation, and neuroprotective signalling pathway engagement