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Both compounds support mitochondrial function, and there is some evidence that supplementation may benefit individuals with primary mitochondrial diseases

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Start your intake Reported Side Effect Incidence Across GLP-1 Classes Semaglutide and tirzepatide report similar gastrointestinal adverse event rates in clinical trials

Beyond lipid metabolism, the GLP-1 RAs also shown critical anti-inflammatory and antioxidant effects, collectively positioning these GLP-1 RAs as a leading pharmacotherapy for MASLD (Pasta et al., 2025