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Unlike drugs that target a single pathway, GHK-Cu acts as a bioregulatory molecule, supporting a wide range of cellular processes

During fetal and early postnatal life, adequate maternal thyroid hormone supply is critical for neurogenesis, neuronal migration, synaptogenesis, and myelination ( The entry of thyroid hormones into the central nervous system depends on specialized transporters at the BBB ( Within the brain, deiodinase enzymes modulate local hormone availability ( At the cellular level, thyroid hormones act through nuclear receptors TR and TR to regulate transcription of genes involved in neuronal metabolism, mitochondrial biogenesis, and cytoskeletal organization (65)

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while omega-3 caused a significant body weight reduction without down-regulating autophagy process and its co-administration with simvastatin enhance its thermogenesis process

Jan 1 2021;36(1):116-129