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Animal studies have demonstrated that a single administration can induce synaptogenic effects-promoting the growth of synapses-that persist for 7 to 14 days

However, qualitative differences, particularly in the high BPA treatment, suggest there may be subtle effects of exposure

Additionally, while there are many benefits of using the 3xTg mouse model of AD 87 , the use of other AD mouse models could provide additional insight, particularly into whether the benefits of CR are mediated via its remediations of tauopathy

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It has also been linked to gasdermin D mediated cell death termed pyroptosis (99)