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Its job is both simple and remarkably important

RS, reactive species

These approaches aim to reduce systemic exposure and off-target effects, thereby mitigating its cytotoxicity

A 2007 double-blind, multicenter trial (n=102) showed ALC 1,500 mg/day significantly improved tender point count, total myalgic score, depression, and musculoskeletal pain compared to placebo.[9] A 2015 RCT found ALC 1,500 mg/day comparable to duloxetine 60 mg/day for pain and depression.[8] Most notably, a 2023 RCT demonstrated that adding PEA 1,200 mg/day + ALC 2,000 mg/day to ongoing duloxetine + pregabalin therapy produced significantly greater improvements in Widespread Pain Index, FIQR, and FASmod scores.[7] Role in Treatment: ALC can be used as monotherapy or adjunctive therapy in fibromyalgia

Supplementing at 6 months is recommended for infants who arent breastfeeding and consume less than 16 ounces (500 mL) of formula per day (4)