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Supplementation with folic acid, or multivitamins containing folic acid, has been associated to better embryo quality, improved chances of pregnancy and reduced risk of ovulatory infertility ( Three enzymes, namely methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR) and methionine synthase reductase (MTRR) exert a major role in both Hcy and folate metabolic pathways (Figure 2)

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Additionally, in oxidative stress cells, Tripartite Motif Containing 22 (TRIM22) has been found to interact with Keap1 and accelerate the ubiquitination and degradation of NRF2, thereby inhibiting oxidative stress progression and activating ROS/AMPK/mTOR/autophagy signaling pathways

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