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472 Elevated extracellular mtDNA in synovial fluid and plasma correlates with autoantibody presence and inflammation, while mtDNA mutations in synovial tissues are associated with increased TNF- and IFN signaling, establishing a self-reinforcing inflammatory cycle

doi:10.6065/apem.2017.22.1.15 Doyle ME, Egan JM

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Morphine injection significantly induced constipated symptoms in mice, including decreased the output and water content of feces, as well as a reduction in both the transit rate and motility of small intestine (Fig