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Its a sign the body is adapting to reduced intake and that adaptation has cellular costs

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Furthermore, when leaked into the extracellular microenvironment, the intermediate metabolites of melanogenesis, which are also immunosuppressive, may promote evasion of immune responses by the initially transformed melanocyte precursors and their offspring melanoma cells, increasing the risk of melanomagenesis and melanoma growth [60]

E., Haskell-Luevano, C