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To this end, Chen et al., has suggested that activation of GLP-1R with liraglutide could protect chondrocytes against endoplasmic reticulum (ER) stress, apoptosis and inflammation by decreasing the release of inflammatory mediators and regulating phosphoinositide 3-kinase (PI3K)/AKT signaling, which suggests that GLP-1R is a therapeutic target for the treatment of OA and that liraglutide could be a therapeutic candidate for clinical application [10]
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Besides flavonoids, other similar bare skeletons exist, such as isoflavonoid, in which the B ring is linked to the C ring at the third position, and neoflavonoid, in which the B ring is attached to the C ring at the fourth position (Fig
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p = 0.008), hypoglycaemia (RR: 1.95
