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Manufacturers exploring these strategies must work through the complexity of the patient journey, understand the impact of formulary access, balance net prices, and work through the logistics of program design

The intestinal epithelium is arranged in a single layer of columnar cells embedded with tight junction proteins [Claudin, Occludin, and Zonula occludens (ZO)] (36), while immunocytes, such as lymphocytes, plasma cells, and macrophages, are present in the lamina propria and participate in intestinal immune defense (37)

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Frimpong et al., 2010), and the average charge state and the relative abundance can then be retrieved for each conformer (Santambrogio et al., 2022), making possible SASA estimation (Kaltashov and Mohimen, 2005