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Dissociated hippocampal neurons were treated with H2O2 for 24hrs +/- HGF at sub-threshold concentrations 5ng/ml and or Dihexa at 2 different concentrations 10 "8 M and 10 "8 M

For BPC-157, the available studies were small, uncontrolled or contradictory

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Additionally, pharmacologic agents such as shikonin (a PKM2 inhibitor) and dichloroacetate (a PDK1 inhibitor) have been shown to suppress TEC apoptosis and attenuate renal interstitial fibrosis (Wei et al., 2019)

However, numerous studies have demonstrated that E2 can inhibit HIF-1 expression via ER (17, 28, 68) or ER (69), presenting contradictory evidence that suggests the existence of alternative pathways through which estrogen may influence HIF-1