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The gastrointestinal tail Nausea, vomiting, diarrhea, and constipation account for the majority of adverse events and the majority of discontinuations within the first year of GLP-1 receptor agonist therapy

You may be more likely to experience semaglutide fatigue if you: Eat too little or skip meals Dont get enough protein Arent drinking enough fluids Increase doses too quickly Lose weight very rapidly Avoid resistance or strength training Have underlying hormone or nutrient imbalances Fatigue isnt a failure, its often a sign your body needs better support

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