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Ultimately, 8 patients (20%) achieved disease control, and 35 (87.5%) experienced no flare-ups over a median 2-year follow-up, suggesting improved disease management (117)

FABP5 also channels PUFAs into cellular membranes, forming PUFA-containing phospholipids that are intrinsically vulnerable to lipid peroxidation and ferroptosis due to their bis-allylic structure with multiple double bonds [5]

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All mice were housed under standard specific pathogen-free (SPF) conditions at the animal core facility (ACF)