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Constipation is also common, reported in around 24% of users across clinical trial populations

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

5lbs down and minimal side effects besides surprised appetite Im into my first month

From celebrity endorsements to social media buzz, these medications have sparked excitement, debate, and many questions