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GLP-1 is produced in the gut in response to food intake and plays a crucial role in regulating blood sugar levels

Research Limitations Limited monotherapy studies: The authors specifically noted that few studies investigate microneedling as a standalone treatment most trials combine it with minoxidil or other topicals

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The exact mechanism is not confirmed, but retatrutide's triple-receptor activity targeting GLP-1, GIP, and glucagon receptors may influence neuroimmune and vasodilatory pathways that affect skin physiology