PIONEER 6 established cardiovascular safety with a favorable nonsignificant point estimate [13]
The clinical read-throughs are accumulating: a randomized trial (Hendershot et al., JAMA Psychiatry 2025) showed semaglutide cut drinks per drinking day, heavy drinking days, and cravings (and even cigarettes) versus placebo
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The effects of topical dexpanthenol on wound healing in humans are unclear
What the drug does to your risk-profile Subcutaneous semaglutide is the only drug in the analysis with high-certainty evidence of reducing the risk of all-cause death (by roughly 19%) and myocardial infarction (by 28%)
