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An update of this investigation [118], which evaluated over 30 studies of 1800 patients with depression treated with omega-3 or placebo, confirmed the superiority of omega-3 over placebo, although the difference, while statistically significant, is modest

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These data are consistent with a role for IGF-I signaling in promoting osteoblast differentiation in early osteoblasts and enhancing mineralizing activities in mature osteoblasts (60)

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