doi:10.1186/s12888-016-0950-2 Hsu CL, Tsai SJ, Shen CC, Lu T, Hung YM, Hu LY
J Trace Elem Med Biol
5-Amino-1MQ is a small molecule that acts as a potent inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT)
Currently, in vivo brain markers in AD and MCI mainly include positron emission tomography scanning of amyloid, tau, and glucose metabolism, as well as brain structural imaging using MRI such as hippocampal atrophy [81]
Therapeutic strategies for targeting ferroptosis It has been over a decade since the term ferroptosis was first introduced, and as research has advanced, several clinical drugs and bioactive pharmacological agents have been identified as modulators of ferroptosis, including inhibitors (Table 2) [113,114,115,116,117,118,119,120,121,122,123,124,125] and inducers (Table 3) [126,127,128,129,130,131,132,133,134,135,136,137,138,139,140]