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The first time we saw this was during the liraglutide trials where blood pressure reduction occurred within 2 weeks of initiation of therapy, which was before any meaningful weight benefit was demonstrated suggesting that weight loss is not the driver of the blood pressure benefits

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Loading phase: 5-10mg twice weekly for 4 weeks

6,7 The ability of GLP-1 and its agonists to cross the bloodbrain barrier 810 suggests its therapeutic potential for NDs

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