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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

These findings underscore the potential of peptide therapy in enhancing recovery outcomes and overall wellness therapy

Cleveland Clinic resources (updated 2025) caution that efficacy claims lack robust RCTs and that purity varies substantially across formulations (1050% active in products)

Brayden, D

Among the most well-known peptides that your body naturally produces and utilises are, for example, insulin, growth hormone, endorphins , and the currently highly discussed hormone GLP-1