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Currently, in vivo brain markers in AD and MCI mainly include positron emission tomography scanning of amyloid, tau, and glucose metabolism, as well as brain structural imaging using MRI such as hippocampal atrophy [81]

More importantly, the orally available RNK06395 ERK5-CHAMP showed promising anti-tumor effects, thus representing a potential ERK5-targeting therapy, since many available ERK5 specific small molecule inhibitors and ERK5 PROTAC are ineffective at reducing cancer cell proliferation [41, 42, 47]