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In the study of endometrial cancer (EC), we found that Brusatol sensitizes the cancer to progestins by inhibiting the NRF2-TET1-AKR1C1 pathway, which reduces AKR1C1 expression and decreases progesterone metabolism [110]

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doi: 10.1046/j.1469-8137.2003.00813.x 85 HajamY

Figure 3 As a key post-transcriptional regulator, miRNA has been demonstrated by several studies to have a significant impact on regulating ferroptosis