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A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study was done to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of orforglipron

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The DHAR enzymes belong to the glutathione S -transferase (GST) superfamily and have a characteristic two-domain architecture, comprised of a mixed / N-terminal domain containing the glutaredoxin motif (CXX[C/S]) and an all-helical C-terminal domain (Littler et al

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