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doi: 10.3389/fimmu.2025.1653378 Received 24 June 2025 Accepted 29 September 2025 Published 03 November 2025 Volume 16 - 2025 Edited by Jing Gao, National Engineering Research Center for Oil Tea, China Reviewed by Jhon Carlos Castao, University of Quindo, Colombia Md

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In PsA, the phase 3b TOGETHER-PsA trial (NCT06588296) assesses the combined use of ixekizumab and tirzepatide in patients with active disease and concomitant overweight or obesity, while the phase 4 TOGETHER AMPLIFY-PsA study (NCT06864026) examines the effectiveness of adding tirzepatide to ixekizumab in clinical practice over 12 months