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Using a spacer device can help deliver medication more effectively to the lungs and reduce medication residue in the mouth, lowering the risk of side effects such as thrush and irritation

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Sikiric et al., 2018) as well as counteracting harmful escape from the initial healing effect (i.e., angiogenesis)

When a compound average effect is only 2 kilograms over 12 weeks, many individual participants likely saw minimal to no change, while a smaller subset may have responded more strongly, pulling the average up