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Eluted peptides were ionized and sprayed into the mass spectrometer using an EasySpray Ion Source (Thermo Fisher Scientific) with a spray voltage of 1.6 kV and a capillary temperature of 275 C

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Consequently, simulations suggest that while doxorubicin redox metabolism impacts GSH metabolism, the concentrations required to illicit a toxic response, with either a single or extended exposure, reside outside that of the therapeutic dosing range

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