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KWONG: So big picture, as a pharmaceuticals person, I know you've talked to many people over the years about GLP-1 drugs

A Bayesian hierarchical model was fitted using the brms framework, specifying percent weight change as a Gaussian outcome with (i) drug-specific smooth dose effects (splines by drug), (ii) treatment duration included as a covariate to account for variability in follow-up time across trials, and (iii) a study-level random intercept to account for between-trial heterogeneity

The companies have known this

The Cleveland Clinic draws an important line: theres a difference between microdosing compounded versions of GLP-1s and working with your doctor to adjust the dose of an FDA-approved medication