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The small intestine has natural defenses against bacterial colonization, including gut motility, stomach acid, and immune surveillance

Many enzymes neutralize ROS, including superoxide dismutase, catalase, glutathione peroxidase (GPX), thioredoxin, peroxiredoxin, and glutathione transferase [82]

Moreover, A on C might be caused by the combination of multiple factors such as decreased prostaglandin synthesis, inflammatory reaction, oxidative stress, abnormal hemodynamics, and increases in the production of thromboxane by the kidney cortex (Gong et al., 2012